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Can ranexa be taken once a day? Dosing Information Initiate RANEXA dosing at 500 mg twice daily and increase to 1000 mg twice daily, as needed, based on clinical symptoms. Take RANEXA with or without meals. Swallow RANEXA tablets whole; do not crush, break, or chew. The maximum recommended daily dose of RANEXA is 1000 mg twice daily.
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